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  • Title: Microwave-assisted one-pot tandem reactions for direct conversion of primary alcohols and aldehydes to triazines and tetrazoles in aqueous media.
    Author: Shie JJ, Fang JM.
    Journal: J Org Chem; 2007 Apr 13; 72(8):3141-4. PubMed ID: 17362044.
    Abstract:
    A series of primary alcohols and aldehydes were treated with iodine in ammonia water under microwave irradiation to give the intermediate nitriles, which without isolation underwent [2+3] cycloadditions with dicyandiamide and sodium azide to afford high yields of the corresponding triazines and tetrazoles, including the alpha-amino- and dipeptidyl tetrazoles in high optical purity.
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