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  • Title: Formulation and evaluation of ketorolac transdermal systems.
    Author: Choi JS, Cho YA, Chun IK, Jung SY, Gwak HS.
    Journal: Drug Deliv; 2007 Feb; 14(2):69-74. PubMed ID: 17364870.
    Abstract:
    The effects of pressure-sensitive adhesives and vehicles on the in vitro permeation of ketorolac and in vivo pharmacokinetics were studied. Duro-Tak 87-2196 showed the highest in vitro permeation profiles, and propylene glycol monolaurate-diethylene glycol monoethyl ether (DGME) (60:40, v/v) and propylene glycol monocaprylate-DGME (60:40, v/v) revealed the most favorable in vitro and in vivo results. The decreased Cmax and prolonged Tmax and half-life were obtained with the ketorolac transdermal systems compared with oral administration, indicating that the ketorolac transdermal systems may have a prolonged effect with reduced toxic event. There was an excellent relationship found between in vitro permeation flux and in vivo AUC0-infinity.
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