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  • Title: Scedosporium prolificans brain abscess in a patient with chronic granulomatous disease: successful combination therapy with voriconazole and terbinafine.
    Author: Bhat SV, Paterson DL, Rinaldi MG, Veldkamp PJ.
    Journal: Scand J Infect Dis; 2007; 39(1):87-90. PubMed ID: 17366022.
    Abstract:
    A patient with chronic granulomatous disease developed brain abscesses with Scedosporium prolificans. In vitro susceptibility revealed a synergistic effect of terbinafine and voriconazole. He received therapy with both these antifungals which resulted in disappearance of the brain abscesses. This is the first reported cure of a CNS S. prolificans infection in an immunocompromised host.
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