These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Upregulation of the brain renin-angiotensin system in rats with chronic renal failure.
    Author: Nishimura M, Takahashi H, Yoshimura M.
    Journal: Acta Physiol (Oxf); 2007 Apr; 189(4):369-77. PubMed ID: 17367405.
    Abstract:
    AIM: We investigated how the brain renin-angiotensin system is involved in regulation of the sympathetic activity and arterial pressure in rats with chronic renal failure. METHODS: Systolic arterial pressure, heart rate and diurnal urinary noradrenaline excretion were measured for 12 weeks in spontaneously hypertensive rats (SHR) with or without subtotal nephrectomy. Expression of mRNAs related to the brain renin-angiotensin system was measured using polymerase chain reaction. Effects of a 6-day intracerebroventricular infusion of a type 1 angiotensin II receptor antagonist (candesartan) or bilateral dorsal rhizotomy on these variables were also investigated. RESULTS: Systolic arterial pressure and urinary excretion of noradrenaline were consistently higher in subtotally nephrectomized SHR than in sham-operated SHR (262 +/- 5 vs. 220 +/- 3 mmHg, P < 0.001; 2.71 +/- 0.22 vs. 1.69 +/-0.19 ng g(-1) body weight day(-1), P < 0.001). Expression of renin, angiotensin-converting enzyme and type 1 angiotensin II receptor mRNAs in the hypothalamus and lower brainstem was greater in subtotally nephrectomized SHR than in sham-operated SHR. Continuous intracerebroventricular infusion of candesartan attenuated hypertension and the increase in urinary noradrenaline excretion in subtotally nephrectomized SHR. Dorsal rhizotomy decreased arterial pressure, urinary excretion of noradrenaline and expression of renin-angiotensin system-related mRNAs in brains of subtotally nephrectomized SHR. CONCLUSION: The brain renin-angiotensin system in subtotally nephrectomized SHR appears to be activated via afferent nerves from the remnant kidney, resulting in sympathetic overactivity and hypertension in this chronic renal failure model.
    [Abstract] [Full Text] [Related] [New Search]