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  • Title: Effect of indomethacin on cerebral blood flow and development of oxygen convulsions.
    Author: Moskvin AN, Alekseeva OS, Gutsaeva DR, Khmel'nitskii AV, Sharapov OI.
    Journal: Bull Exp Biol Med; 2006 Jul; 142(1):26-8. PubMed ID: 17369894.
    Abstract:
    Hyperbaric oxygenation modulates cerebral blood flow affecting the development of oxygen convulsions. Before hyperbaric oxygenation-induced convulsions in rats the initial decrease in blood flow gave place to hyperemia, Po(2) increased. In rats receiving cyclooxygenase inhibitor indomethacin no convulsions were observed, blood flow and Po(2)were lower than in controls. Our results indicate that indomethacin prevents hyperemia and alleviates oxygen convulsions under conditions of hyperbaric oxygenation.
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