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  • Title: [Rhodococcus equi infection in subjects infected with human immunodeficiencv virus (HIV)].
    Author: Rozsypal H, Aster V, Stahiková M, Horová B.
    Journal: Cas Lek Cesk; 2007; 146(2):163-7. PubMed ID: 17373114.
    Abstract:
    Disease caused by Rhodococcus equi is a rare complication in subjects infected with human immunodeficiency virus (HIV) and it is associated with severe cellular immunodeficiency. The agent is gram-positive rod of the group non-diphtheric corynebacteria. The genus Rhodococcus belongs to the family Nocardiaceae and order Actinomycetales. The principle of pathogenicity is the survival inside macrophages. Formation of necrotising granulomas is a characteristic feature. Malacoplakia can be a specific cytological finding. Symptoms of disease include wet cough, fever and pleuritic chest pain. Problems persist many weeks before admission to the hospital. Chest X-ray and CT scan of the lungs show cavitary pulmonary lesions. Agents grow not only from the sputum specimen and also from samples received by bronchoscopy. In 50% of cases it can be revealed in hemoculture. Outcome is poor; mortality rate is reported to be over 30%. Better survival can be found in subjects who managed efficient antiretroviral therapy. Recommended treatment of Rhodococcus equi pneumonia includes particularly vancomycin, amikacin, rifampicin, imipenem, ciprofloxacin and erythromycin. Rhodococcus equi infection in an HIV positive subject is reported in case study of 52-year old man with AIDS with cavitary necrotising pneumonia and induced pericarditis, where the agent grew in hemoculture. This Rhodococcus equi pneumonia is the first case and till now the only one Rhodococcus infection in HIV patients described in the Czech Republic.
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