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  • Title: [Bisphosphonates-associated osteonecrosis of the jaw: review on reported cases].
    Author: Gering A, Grange L, Villier C, Woeller A, Mallaret M.
    Journal: Therapie; 2007; 62(1):49-54. PubMed ID: 17374348.
    Abstract:
    Osteonecrosis of the jaws associated with the use of bisphosphonates (alendronate, pamidronate, risedronate et zoledronate) are described as an avascular necrosis. We have listed 184 cases of bisphosphonates-associated osteonecrosis of the maxillary in the literature. Many mechanisms are discussed in bisphosphonates-associated osteonecrosis: a disturbing bone turnover, an accumulation of bone's microdamage or an antiangiogenic effect. Other risk factors seem however to be involved: cancer, chemotherapy, glucocorticoids, infection and renal insufficiency.
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