These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Agmatine blocks morphine-evoked hyperthermia in rats.
    Author: Rawls SM, Amin M, Zisk J.
    Journal: Brain Res; 2007 May 25; 1147():89-94. PubMed ID: 17376409.
    Abstract:
    The present study investigated the effect of agmatine on morphine-evoked hyperthermia in rats. Morphine (4 mg/kg, s.c.) produced hyperthermia by activating mu opioid receptors. Agmatine (10 and 50 mg/kg, i.p.) was ineffective. For combined administration, agmatine decreased morphine-evoked hyperthermia. The effect was prevented by idazoxan (5 mg/kg, i.p.), an imidazoline/alpha(2)-adrenoeceptor receptor antagonist. Yohimbine, an alpha(2)-adrenoeceptor antagonist, did not prevent the attenuation of morphine-evoked hyperthermia by agmatine. The present data provide pharmacological evidence that agmatine blocks the hyperthermic effect of morphine by activating imidazoline receptors.
    [Abstract] [Full Text] [Related] [New Search]