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  • Title: Ribosomal protein S1 is not essential for the trans-translation machinery.
    Author: Qi H, Shimizu Y, Ueda T.
    Journal: J Mol Biol; 2007 May 04; 368(3):845-52. PubMed ID: 17376482.
    Abstract:
    In eubacteria, ribosome stalling during protein synthesis is rescued by a tmRNA-derived trans-translation system. Because ribosomal protein S1 specifically binds to tmRNA with high affinity, it is considered to be involved in the trans-translation system. However, the role of S1 in trans-translation is still unclear. To study the function of S1 in the trans-translation system, we constructed an S1-free cell-free translation system. We found that trans-translation proceeded even in the absence of S1. Addition of S1 into the S1-free system did not affect trans-translation efficiency. These results suggest that S1 does not play a role in the trans-translation machinery.
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