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  • Title: Structural assignment of poecillastrins B and C, macrolide lactams from the deep-water Caribbean sponge Poecillastra species.
    Author: Takada K, Choi BW, Rashid MA, Gamble WR, Cardellina JH, Van QN, Lloyd JR, McMahon JB, Gustafson KR.
    Journal: J Nat Prod; 2007 Mar; 70(3):428-31. PubMed ID: 17378533.
    Abstract:
    Two new chondropsin-type macrolide lactams, poecillastrins B (1) and C (2), were isolated from aqueous extracts of the marine sponge Poecillastra sp. These trace metabolites were isolated in low yield (400-600 microg), and their structures were determined primarily by analysis of NMR data acquired using a cyrogenically cooled probe. High-quality 1D and 2D NMR data sets allowed complete assignment of the spectroscopic data and defined the new structures as 35-membered ring analogues of poecillastrin A (3). Compounds 1 and 2 showed potent cytotoxic activity against a human melanoma tumor cell line (LOX) with an IC50 value of less than 1 microg/mL.
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