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  • Title: Leachianone A as a potential anti-cancer drug by induction of apoptosis in human hepatoma HepG2 cells.
    Author: Cheung CS, Chung KK, Lui JC, Lau CP, Hon PM, Chan JY, Fung KP, Au SW.
    Journal: Cancer Lett; 2007 Aug 18; 253(2):224-35. PubMed ID: 17379399.
    Abstract:
    The Chinese herbal medicine Radix Sophorae is widely applied as an anti-carcinogenic/ anti-metastatic agent against liver cancer. In this study, Leachianone A, isolated from Radix Sophorae, possessed a profound cytotoxic activity against human hepatoma cell line HepG2 in vitro, with an IC(50) value of 3.4microg/ml post-48-h treatment. Its action mechanism via induction of apoptosis involved both extrinsic and intrinsic pathways. Its anti-tumor effect was further demonstrated in vivo by 17-54% reduction of tumor size in HepG2-bearing nude mice, in which no toxicity to the heart and liver tissues was observed. In conclusion, this is the first report describing the isolation of Leachianone A from Radix Sophorae and the molecular mechanism of its anti-proliferative effect on HepG2 cells.
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