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  • Title: Epinephrine-induced enhancement of memory retrieval for inhibitory avoidance conditioning in preweanling Sprague-Dawley rats.
    Author: Flint RW, Bunsey MD, Riccio DC.
    Journal: Dev Psychobiol; 2007 Apr; 49(3):303-11. PubMed ID: 17380503.
    Abstract:
    Developmental research on memory is commonly conducted using preweanling rats, but the extent to which these animals are susceptible to hormone-induced memory retrieval is unclear. This study examined the effects of epinephrine (.001, .01, or .1 mg/kg) on retrieval of IA conditioning in 17-day-old infants. Animals tested 24 hr following training performed significantly worse than infants tested 5 min after training and adults tested 24 hr later, indicating that infantile amnesia had occurred. Epinephrine attenuated this deficit in a dose-dependent manner, with a significant improvement in performance at doses of .01 mg/kg for latency and at .01 and .1 mg/kg for safe side-dependent measures. The role of epinephrine as a memory modulator is discussed in terms of its neurobiological and internal contextual effects.
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