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  • Title: Novel small-molecule inhibitors of the vascular endothelial growth factor receptor.
    Author: Adjei AA.
    Journal: Clin Lung Cancer; 2007 Feb; 8 Suppl 2():S74-8. PubMed ID: 17382028.
    Abstract:
    Sustained angiogenesis is one of the hallmarks of carcinogenesis. Vascular endothelial growth factor (VEGF) is a critical molecule mediating pro-angiogenic signals against which a number of therapeutic approaches have been designed. The 2 predominant approaches to inhibiting VEGF signalling are the use of monoclonal antibodies to block the receptor or ligand and small molecule receptor kinase inhibitors. There are several small-molecule inhibitors of tyrosine kinase activity of VEGF receptors in clinical trials. These are discussed in this review.
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