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  • Title: Radioresistance of Micrococcus radiodurans during the growth cycle.
    Author: Serianni RW, Bruce AK.
    Journal: Radiat Res; 1968 Nov; 36(2):193-207. PubMed ID: 17387939.
    Abstract:
    Micrococcus radiodurans, irradiated aerobically in phosphate buffer, exhibits a phasic response to x-irradiation during its growth cycle. The culture progresses from a relatively sensitive state during the exponential portion of the growth cycle to a highly resistant state during the stationary phase. The shift in resistance is characterized by a marked extension of the shoulder of the survival curve and a threefold increase in the LD99 from 250 kR to over 700 kR. The resistant state appears to be a metastable condition, readily induced in exponential-phase cultures and easily reversed in stationary-phase cultures. Similar variations are not elicited in response to ultraviolet irradiation. The phasic response does not appear to be the result of a low-molecular-weight extractable sulfhydryl radioprotective agent.
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