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  • Title: Orientation of the complementary strands of polyoma virus DNA with respect to the DNA physical map.
    Author: Kamen R, Sedat J, Ziff E.
    Journal: J Virol; 1975 Jan; 17(1):212-8. PubMed ID: 173885.
    Abstract:
    The chemical polarities of the two strands of polyoma virus DNA with respect to the DNA physical map have been determined by hybridization of restriction endonuclease fragments specifically labeled with [125I]dCMP at their 3' termini to asymmetric polyoma complementary RNA (the product of in vitro transcription of viral DNA by Escherichia coli RNA polymerase). The orientations of the polyoma-specific stable RNA transcripts present in the cytoplasm of productively linfected mouse cells have been deduced from this result: the 5' ends of the early and late viral transcripts map very near the origin of viral DNA replication.
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