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  • Title: Non-fouling microfluidic chip produced by radio frequency tetraglyme plasma deposition.
    Author: Salim M, Mishra G, Fowler GJ, O'sullivan B, Wright PC, McArthur SL.
    Journal: Lab Chip; 2007 Apr; 7(4):523-5. PubMed ID: 17389972.
    Abstract:
    This Technical Note presents the direct surface modification of a glass/PTFE hybrid microfluidic chip, via radio frequency glow discharge plasma polymerisation of tetraethlylene glycol dimethylether (tetraglyme), to produce hydrophilic, non-fouling, PEO-like surfaces. We use several techniques including X-ray photoelectron spectroscopy (XPS), direct enzyme-linked immunosorbent assays (ELISA) and immunofluorescent imaging to investigate the channel coatings. Our results indicate the successful deposition of a PEO-like coating onto microchannel surfaces that has both solution and shelf stability (>3 months) and is capable of preventing fibrinogen adsorption to the microchannel surfaces.
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