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  • Title: Anticancer drugs from nature--natural products as a unique source of new microtubule-stabilizing agents.
    Author: Altmann KH, Gertsch J.
    Journal: Nat Prod Rep; 2007 Apr; 24(2):327-57. PubMed ID: 17390000.
    Abstract:
    This review article provides an overview on the current state of research in the area of microtubule-stabilizing agents from natural sources, with a primary focus on the biochemistry, biology, and pharmacology associated with these compounds. A variety of natural products have been discovered over the last decade to inhibit human cancer cell proliferation through a taxol-like mechanism. These compounds represent a whole new range of structurally diverse lead structures for anticancer drug discovery.
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