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Title: Anti-leishmania activity of semi-purified fraction of Jacaranda puberula leaves. Author: Passero LF, Castro AA, Tomokane TY, Kato MJ, Paulinetti TF, Corbett CE, Laurenti MD. Journal: Parasitol Res; 2007 Aug; 101(3):677-80. PubMed ID: 17390147. Abstract: The crude methanolic extract from leaves of Jacaranda puberula showed activity against Leishmania (Leishmania) amazonensis. The extract presented active against promastigote forms with an inhibitory concentration 50% (IC(50)) value of 88.0 mug/ml, but only moderated activity against amastigote forms; however in higher concentrations the extract showed cytotoxic effects. The bio-guided chromatographic fractionation the crude methanolic extract against amastigotes yielded a fraction with an IC(50) value of 14.0 mug/ml (without cytotoxic activity) in relation to the crude extract (IC(50) value, 359.0 microg/ml). These data indicate that J. puberula leaves contain active compounds, which should be further investigated for the development of new potential drugs against cutaneous leishmaniasis.[Abstract] [Full Text] [Related] [New Search]