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  • Title: Reduction of background mutations by low-dose X irradiation of Drosophila spermatocytes at a low dose rate.
    Author: Koana T, Okada MO, Ogura K, Tsujimura H, Sakai K.
    Journal: Radiat Res; 2007 Feb; 167(2):217-21. PubMed ID: 17390729.
    Abstract:
    A sex-linked recessive lethal mutation assay was performed in Drosophila melanogaster using immature spermatocytes and spermatogonia irradiated with X rays at a high or low dose rate. The mutation frequency in the sperm irradiated with a low dose at a low dose rate was significantly lower than that in the sham-irradiated group, whereas irradiation with a high dose resulted in a significant increase in the mutation frequency. It was obvious that the dose-response relationship was not linear, but rather was U-shaped. When mutant germ cells defective in DNA excision repair were used instead of wild-type cells, low-dose irradiation at a low dose rate did not reduce the mutation frequency. These observations suggest that error-free DNA repair functions were activated by low dose of low-dose-rate radiation and that this repaired spontaneous DNA damage rather than the X-ray-induced damage, thus producing a practical threshold.
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