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  • Title: Development of an HPLC method for the determination of doripenem in human and mouse serum.
    Author: Sutherland C, Nicolau DP.
    Journal: J Chromatogr B Analyt Technol Biomed Life Sci; 2007 Jun 15; 853(1-2):123-6. PubMed ID: 17392039.
    Abstract:
    A HPLC method utilizing solid phase extraction was developed to analyze doripenem (formerly S-4661) in human and mouse serum. A reversed-phase column was used with a UV detector set at 295 nm. The mobile phase consisted of methanol and phosphate buffer at a flow rate of 1.5 ml/min. Meropenem was used as the internal standard. The standard curve was linear over a range of 0.5-40 microg/ml. The assay is simple, reproducible, and accurate and has been used successfully to analyze doripenem concentrations from a murine pharmacokinetic study.
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