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  • Title: Relationship between human leucocyte antigen class I and class II and chronic idiopathic urticaria associated with aspirin and/or NSAIDs hypersensitivity.
    Author: Pacor ML, Di Lorenzo G, Mansueto P, Martinelli N, Esposito-Pellitteri M, Pradella P, Uxa L, Di Fede G, Rini G, Corrocher R.
    Journal: Mediators Inflamm; 2006; 2006(5):62489. PubMed ID: 17392574.
    Abstract:
    BACKGROUND: HLA genes play a role in the predisposition of several diseases. The aim was to analyze the prevalence of HLA class I phenotypes and HLA-DRB1* genotype in patients with CIU associated with ASA and NSAIDs hypersensitivity (AICU). METHODS: 69 patients with AICU, and 200 healthy subjects. RESULTS: Subjects with HLA-B44 and HLA-Cw5 antigens were more represented in patients with AICU than in control group. Subjects with HLA-A11, HLA-B13, HLACw4, and HLA-Cw7 antigen were more represented in control group than in patients with AICU. Multiple logistic regression demonstrated an association of HLA-Cw4 and HLA-Cw7 with a lower risk of AICU, whereas carriers of HLA-B44 phenotype had a higher risk of AICU. No differences were found between patients and controls as regards to HLA-DRB1* genotype. CONCLUSIONS: We observed an association between some HLA class-I antigens and AICU. To the best of our knowledge this is the first description of such association.
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