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  • Title: Amantadine-resistant influenza A in a nursing facility.
    Author: Degelau J, Somani SK, Cooper SL, Guay DR, Crossley KB.
    Journal: Arch Intern Med; 1992 Feb; 152(2):390-2. PubMed ID: 1739371.
    Abstract:
    Rapid index case treatment and amantadine prophylaxis were implemented in two nursing homes exposed to influenza A. Facility A had no isolation of cases, and 18 of 22 cases occurred after amantadine hydrochloride therapy was initiated. Three patients exhibited amantadine-resistant virus. Facility B had day 1 isolation of the index case. A facility-wide outbreak did not occur. The experience of these facilities suggests that concurrent amantadine treatment and prophylaxis without adequate case isolation may promote further influenza A infection in a nursing facility.
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