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  • Title: Effects of different amounts of a low fluoride toothpaste on primary enamel lesion progression: a preliminary study using in vitro pH-cycling system.
    Author: Itthagarun A, Thaveesangpanich P, King NM, Tay FR, Wefel JS.
    Journal: Eur Arch Paediatr Dent; 2007 Mar; 8(1):69-73. PubMed ID: 17394894.
    Abstract:
    AIMS: To evaluate and compare the efficacy of pea and half-pea portions of child formula fluoride (500 ppm) toothpaste on artificially created enamel lesions in primary teeth. METHODS: Sound primary incisors were painted with nail varnish, leaving a 1 mm wide window and then placed in a demineralising solution for 96 h to produce artificial carious lesions 60-100 microm deep. The teeth were longitudinally sectioned (100 microm thick) and divided into 3 groups. Group A: treated with a pea-sized portion of a non-fluoride containing toothpaste (1:3, toothpaste: deionized water), while Groups B and C were treated with half-pea-sized and pea-sized portions of a 500 ppm fluoride containing toothpaste, respectively. The pH-cycling model was utilized for 7 days. RESULTS: Groups A and B lesions increased in depth by 60% while those in Group C increased by 19%. The mineral content of the surface zone decreased significantly in Groups A and B but not in Group C. CONCLUSION: Reduction of the amount of fluoride toothpaste to less than a pea-size in order to minimize the risk of fluorosis should be undertaken with caution because it may compromise the cariostatic effects of the toothpaste.
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