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  • Title: QTc prolongation and torsades de pointes associated with methadone therapy.
    Author: Routhier DD, Katz KD, Brooks DE.
    Journal: J Emerg Med; 2007 Apr; 32(3):275-8. PubMed ID: 17394991.
    Abstract:
    Oral methadone therapy is an effective and increasingly popular treatment for opioid dependency and chronic pain. Although it is not typically considered pro-dysrhythmic, we present the unique case of a 52-year-old HIV-positive woman without underlying cardiac disease who developed QTc prolongation and pulseless Torsades secondary to high dose methadone therapy.
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