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  • Title: A multi-center phase II study of weekly topotecan as second-line therapy for small cell lung cancer.
    Author: Shah C, Ready N, Perry M, Kirshner J, Gajra A, Neuman N, Garziano S.
    Journal: Lung Cancer; 2007 Jul; 57(1):84-8. PubMed ID: 17399850.
    Abstract:
    PURPOSE: To determine the response rate, toxicity, failure free and overall survival of weekly topotecan in patients with relapsed small cell lung cancer who received one prior platinum based chemotherapy. PATIENTS AND METHODS: Twenty two patients with relapsed disease after response to one prior chemotherapy with or without radiotherapy and patients with relapse more than 90 days after their last therapy received topotecan 4mg/m(2) intravenous over 30min on days 1,8,15; every 4 weeks (3 weeks on and 1 weeks off). Chemotherapy was given until disease progression or unacceptable toxicity. RESULTS: Of 22 patients, none of the patients responded to weekly topotecan therapy. Four patients had stable disease. After a median follow up of 1 year, median time to progression was 6 weeks and median survival was 5 months. The common toxicities associated with this regimen were anemia, thrombocytopenia, fatigue, GI side effects and alopecia. CONCLUSION: Weekly topotecan was well tolerated but ineffective in this trial. Although commonly used, weekly regimen of topotecan should be used with caution in relapsed SCLC.
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