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  • Title: 10-Hydroxycamptothecin loaded nanoparticles: preparation and antitumor activity in mice.
    Author: Zhang L, Yang M, Wang Q, Li Y, Guo R, Jiang X, Yang C, Liu B.
    Journal: J Control Release; 2007 Jun 04; 119(2):153-62. PubMed ID: 17400320.
    Abstract:
    10-Hydroxycamptothecin (HCPT) loaded nanoparticles made from poly(caprolactone-co-lactide)-b-PEG-b-poly(caprolactone-co-lactide) (PCLLA-PEG-PCLLA) block copolymer, were prepared by a novel two-step nanoprecipitation method using an interior-chemistry strategy. The satisfactory drug loading content (>13%) as well as high encapsulation efficiency (>85%) was achieved. Cytotoxicity test indicated that the HCPT-loaded nanoparticles had enhanced in vitro cytotoxicity compared to free drug. Progressively, in vivo antitumor activity and HCPT biodistribution in sarcoma-180 (S-180) bearing mice after intravenous injection of the HCPT-loaded nanoparticles show that HCPT-loaded nanoparticles exhibited superior in vivo antitumor effect and remarkably different biodistribution than the commercially available HCPT injection.
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