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  • Title: The renin system: is direct renin inhibition different from blockade at the AT1 receptor or the ACE step?
    Author: Hollenberg NK.
    Journal: Rev Cardiovasc Med; 2007; 8 Suppl 2():S7-13. PubMed ID: 17401314.
    Abstract:
    A substantial level of evidence supports the use of renin system blockade for many patients with hypertension. Two lines of evidence, based on very high-dose angiotensin blocker treatment or combination therapy with angiotensin-converting enzyme inhibitor and angiotensin receptor blocker, suggest that more complete blockade leads to improved clinical outcomes. The recent development of a powerful renin inhibitor that acts at the initial, rate-limiting step in the renin cascade would also favor more complete blockade of the system. For many patients, this is likely to lead to improved treatment.
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