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  • Title: Outcome of a national Israeli cohort of pediatric systemic lupus erythematosus.
    Author: Uziel Y, Gorodnitski N, Mukamel M, Padeh S, Brik R, Barash J, Mevorach D, Berkun Y, Tauber T, Press J, Harel L, Navon P, Rubenstein M, Naparstek Y, Hashkes PJ, Pediatric Rheumatology Study Group Of Israel @ SLERI.
    Journal: Lupus; 2007; 16(2):142-6. PubMed ID: 17402372.
    Abstract:
    The aim of this study was to describe the clinical manifestations and outcomes of a national cohort of childhood systemic lupus erythematosus (cSLE). All cases of cSLE registered in the Israeli national registry of children with rheumatic diseases between 1987-2003 were examined for disease activity and damage by the SLE disease activity index (SLEDAI) and SLE collaborating clinics/American College of Rheumatology (SLICC/ACR) damage index. Demographic, clinical, laboratory and treatment factors were analysed for their effect on the outcome. One-hundred and two patients were identified, 81% females, with a mean age at diagnosis of 13.3 +/- 2.6 years. The mean SLEDAI score was 17.2 +/- 9.0 (range 2-60). Fifty four patients were followed for at least five years. The mean SLEDAI decreased to 7.6 +/- 6.3 (0-29) and the mean SLICC/ACR damage index was 0.7 +/- 1.6 (0-8). Five patients developed chronic renal failure. No patients died. No factors were found to be significantly associated with the outcome except the initial SLEDAI score. The five-year outcome of our national cSLE cohort was good; with relatively low activity and minimal damage in most patients. The initial SLEDAI predicted the development of late damage.
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