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  • Title: Generalized seizures following topical lidocaine administration during circumcision: establishing causation.
    Author: Rezvani M, Finkelstein Y, Verjee Z, Railton C, Koren G.
    Journal: Paediatr Drugs; 2007; 9(2):125-7. PubMed ID: 17407368.
    Abstract:
    We report a case of neonatal seizures after lidocaine administration for circumcision. A 3-month-old male infant received an overdose as evidenced by toxic lidocaine levels and developed generalized seizures shortly after. Back extrapolation of the serum lidocaine concentration to time zero was used to determine the administered dose. The Naranjo scale was used to determine causation; probable causation was defined. Particular care must be taken to administer an appropriate dose of local anesthetics in infants to avoid life-threatening seizures.
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