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  • Title: Atopic dermatitis: insights from linkage overlap and disease co-morbidity.
    Author: Willis-Owen SA, Morar N, Willis-Owen CA.
    Journal: Expert Rev Mol Med; 2007 Apr 03; 9(9):1-13. PubMed ID: 17407613.
    Abstract:
    Atopic dermatitis (AD) is a strongly heritable, chronic relapsing dermatosis that frequently co-occurs with other atopic phenotypes including asthma and allergic rhinitis (the so-called atopic triad disorders). However, despite high levels of co-morbidity, relatively low levels of genomic co-incidence have been observed between atopic triad disorders. Conversely, current mapping data have revealed a striking pattern of co-localisation between AD disease loci and those mapped using another chronic dermatological disease - psoriasis. In this review, we examine the evidence for co-localisation between AD and a range of atopic, infectious, inflammatory and autoimmune diseases, and consider the implications of these data for the AD disease concept and future research in the field.
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