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  • Title: [Development of respiratory function in perinatal ontogenesis].
    Author: Bursian AV.
    Journal: Zh Evol Biokhim Fiziol; 2007; 43(1):24-31. PubMed ID: 17408089.
    Abstract:
    In development of respiratory function in rats, mice, and other representatives of placental animals there exists the general plan of formation of rhythm: from single contraction of respiratory musculature to formation of bursts and complexes alternating periodically with pauses and apnea intervals and subsequent rhythm stabilization. These peculiarities are closely connected with the states of sleep and consciousness. A concept is put forward about a certain sequence of functional maturation and ways of regulation of activity of the respiratory rhythm central pacemaker. At the first stage the autogenic rhythmical activity is determined by pacemaker properties of a part of neurons of the medulla rostral ventrolateral part. It is not ruled out that the first respiratory discharges in spinal cord ventral roots might have been a manifestation of the nervous network rhythmogenic properties. The direct sensitivity of central neurons to chemical composition if the medium and to some neutomodulators serves as the first regulatory mechanism. Somewhat later, inhibitory control is established from supramedullary structures, with an increase of role of peripheral receptors in regulation of respiration.
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