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  • Title: Improving the comparability of immunoassays for prostate-specific antigen (PSA): progress and problems.
    Author: Sturgeon CM, Ellis AR.
    Journal: Clin Chim Acta; 2007 May; 381(1):85-92. PubMed ID: 17408608.
    Abstract:
    BACKGROUND: Commutability of immunoassay test results is an important objective for laboratory medicine. METHODS: PSA is a clinically important analyte for which, as a consequence of a number of national and international initiatives over the last decade, considerable progress has been made towards improving method comparability. However, results from different assays are still not interchangeable, a situation that is only likely to improve once broad recommendations can be made about the most clinically relevant antibody combinations. CONCLUSIONS: Universal implementation of such recommendations would almost certainly improve between-method agreement substantially, provided careful attention were paid to assay design and use of appropriately pure secondary standards ensured.
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