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  • Title: Signal input for a chemotactic response in the cellular slime mold Dictyostelium discoideum.
    Author: Mato JM, Losada A, Nanjundiah V, Konijn TM.
    Journal: Proc Natl Acad Sci U S A; 1975 Dec; 72(12):4991-3. PubMed ID: 174088.
    Abstract:
    Drops with different concentrations of 3':5'-cyclic AMP were deposited at various distances from small populations of Dictyostelium discoideum amoebae, and the distances over which 50% of the amoebae drops reacted positively were determined. The linear regression analysis of a bouble logarithmic plot of distance against concentration gives a straight line with a slope of 1/4.25, which value suggests that the amoebae respond to a spatial gradient of cyclic AMP concentration. The threshold value for the signal is 3.6 X 10(-9) M/mm with a sensitivity of measurement of about 1%. These findings are discussed in relation to our present knowledge of cyclic AMP receptors.
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