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  • Title: Strength-duration properties in diabetic polyneuropathy.
    Author: Yerdelen D, Koç F, Uysal H, Sarica Y.
    Journal: Diabetes Res Clin Pract; 2007 Oct; 78(1):56-9. PubMed ID: 17408800.
    Abstract:
    We sought to examine the changes in the strength-duration time constant (SDTC) of the median nerve in diabetic polyneuropathy. The SDTC is a measure of axonal excitability and depends on the biophysical properties of the axonal membrane. It may provide some information about Na(+) channel functioning. Forty-nine diabetic patients (30 men, 19 women; mean age, 54.6+/-9.4 years) and 15 age-matched healthy subjects (11 men, 4 women; mean age, 53.1+/-7.6 years) participated in the study. SDTC and rheobase values were 384.5+/-97.9 micros and 4.6+/-2.4 mA in patients and 313.8+/-46.7 micros and 6.0+/-2.6 mA in controls. The SDTC was found to be significantly different between the two groups (P=.009 for SDTC and P=.066 for rheobase). Fasting glucose and HbA1c levels of patients were 206.6+/-88.7 mg/dL and 8.8+/-2.4%, and these were not correlated with SDTC or rheobase (P<.05). We suggest that longer SDTC, indicating increased axonal excitability may develop in patients with polyneuropathy associated with uncontrolled diabetes.
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