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  • Title: Determination of eprosartan in human plasma and urine by LC/MS/MS.
    Author: Li XN, Xu HR, Chen WL, Liu GY, Chu NN, Yu C.
    Journal: J Chromatogr B Analyt Technol Biomed Life Sci; 2007 Jun 15; 853(1-2):47-53. PubMed ID: 17409033.
    Abstract:
    A protein precipitation, liquid chromatography/tandem mass spectrometry (LC/MS/MS) method has been developed and validated for the determination of eprosartan in human plasma and urine. The solvent system also served as a protein precipitation reagent. The chromatographic separation was achieved on a CAPCELL PAK C18 column (50 mmx2.0 mm, 5 microm, Shiseido). A mobile phase was consisted of 0.5% formic acid in water and 0.5% formic acid in acetonitrile (72:28). Detection was by positive ion electrospray tandem mass spectrometry on a Sciex API3000. The standard curves, which ranged from 5 to 2000 ng/mL in human plasma and from 0.25 to 50 microg/mL in urine, were fitted to a 1/x weighted quadratic regression model. The method proved to be accurate, specific and sensitive enough to be successfully applied to a pharmacokinetic study.
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