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  • Title: Risk factors for auditory neuropathy/auditory synaptopathy.
    Author: Beutner D, Foerst A, Lang-Roth R, von Wedel H, Walger M.
    Journal: ORL J Otorhinolaryngol Relat Spec; 2007; 69(4):239-44. PubMed ID: 17409783.
    Abstract:
    AIMS: It was the aim of this study to describe risk factors in auditory neuropathy/auditory synaptopathy (AN/AS). METHODS: Between 1997 and 2005, we diagnosed 37 children with AN/AS. They underwent a critical chart review for risk factors and etiological coincidences in this idiosyncratic disorder. RESULTS: Eighteen neonates had a history of prematurity and low birth weight. Hyperbilirubinaemia was present in 13 children. Three patients had evidence of infection during pregnancy, and AN/AS was associated with complex syndromal diseases in 2 cases. A congenital, familial pattern was seen in 2 siblings. Seven patients had idiopathic AN/AS. CONCLUSION: Rather than being a single etiological entity, AN/AS comprises a spectrum of risk factors and associated problems affecting the cochlea and the auditory pathway. This study shows that the majority of AN/AS in children is the result of perinatal problems and is not genetic in origin. Hyperbilirubinaemia is a common and etiologically significant finding in infants suffering from AN/AS. Thus, early hearing screening for AN/AS including transient evoked otoacoustic emissions and auditory brainstem response assessment among neonates with risk factors for AN/AS is crucial in order to better manage patients suffering from this disorder.
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