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  • Title: Toll-like receptor 4 Asp299Gly polymorphism is associated with an increased risk of pancreatic necrotic infection in acute pancreatitis: a study in the Chinese population.
    Author: Gao HK, Zhou ZG, Li Y, Chen YQ.
    Journal: Pancreas; 2007 Apr; 34(3):295-8. PubMed ID: 17414051.
    Abstract:
    OBJECTIVES: To detect the frequency of Toll-like receptor (TLR) 4896A>G (Asp299Gly) polymorphism in acute pancreatitis (AP) patients and to determine the relationship between polymorphism and pancreatic necrotic infection. METHODS: The allele frequency of TLR4 Asp299Gly was surveyed by mispairing polymerase chain reaction-restriction fragment length polymorphism analysis technique in AP patients with pancreatic necrosis and healthy volunteers, respectively. RESULTS: All individuals with TLR4 Asp299Gly polymorphism were heterozygotes. Compared with healthy volunteers (5.6%), TLR4 896G allele frequencies was significantly higher in AP patients with pancreatic infection (20%), the incidence of gram-negative infection was significantly higher in AP patients with TLR4 Asp299Gly polymorphism (15 [44%]/34) than that in AP patients without TLR4 polymorphism (15 [18%]/81). CONCLUSIONS: Toll-like receptor 4 Asp299Gly polymorphism is associated with the infection of pancreatic necrosis in AP. Patients who carried TLR4 896A>G mutation is susceptible to pancreatic gram-negative bacteria infection.
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