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  • Title: trans-(1R,2R)-Diaminocyclohexane-functionalized mesoporous organosilica spheres as chiral stationary phase.
    Author: Zhu G, Jiang D, Yang Q, Yang J, Li C.
    Journal: J Chromatogr A; 2007 May 18; 1149(2):219-27. PubMed ID: 17418852.
    Abstract:
    The bifunctionalized mesoporous organosilica spheres with trans-(1R,2R)-diaminocyclohexane (DACH) in the pore were synthesized and their application as chiral stationary phase in high-performance liquid chromatography (HPLC) was demonstrated. Bifunctionalized mesoporous organosilica spheres with narrow particle size distribution of 5-7 microm were prepared by the co-condensation of N-[3-(triethoxysilyl)propyl]-trans-(1R,2R)-diaminocyclohexane (M(propyl)) with 1,2-bis(trimethoxysilyl)ethane (BTME) in basic medium using octadecyltrimethylammonium chloride (C(18)TACl) as structural directing agent and ethanol as co-solvent. The morphologies of the bifunctionalized mesoporous organosilicas were sensitive to the molar fraction of M(propyl). At higher M(propyl)/BTME molar ratio, the bifunctionalized organosilica spheres with ordered mesoporous structure can be formed in a wide range of synthetic conditions. When the molar percent of M(propyl)/(M(propyl)+BTME) is less than 20, the formation of spheres could be hardly observed. The structural order of the materials mainly depends on the base concentration and M(propyl)/BTME molar ratio in the initial sol mixture. A column packed with the bifunctionalized mesoporous organosilica spheres exhibits higher selectivity and resolution for racemic amino acids than that packed with DACH-SiO(2) prepared by conventional post-synthesis grafting method.
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