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  • Title: Role of surfactants in clouding phenomenon of imipramine hydrochloride.
    Author: Alam MS, Naqvi AZ, Kabir-Ud-Din.
    Journal: Colloids Surf B Biointerfaces; 2007 Jun 15; 57(2):204-8. PubMed ID: 17419011.
    Abstract:
    The clouding behavior of tricyclic antidepressant drug imipramine hydrochloride (IMP) in aqueous solution has been studied in presence of surfactants. A pH increase in the presence as well as in the absence of surfactants decreased the CP. Drug molecules become neutral at high pH and therefore head-head repulsion decreases which lead to CP decrease. Addition of non-ionic and cationic surfactants increased the CP whereas anionic surfactants showed a peaked profile. Effect of CTAB/TX-100 at different fixed drug concentrations showed that at all surfactant concentrations the CP value was higher for higher drug concentrations. However, variation of pH produced opposite effect: CP at all CTAB/TX-100 concentrations decreased with increasing pH. All results are interpreted in terms of increase in hydrophobicity or hydrophilicity of micelles on addition of surfactants.
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