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  • Title: Relationship between cytokine response and temporary ventilation during one-lung ventilation in esophagectomy.
    Author: Ojima H, Kuwano H, Kato H, Miyazaki T, Nakajima M, Sohda M, Tsukada K.
    Journal: Hepatogastroenterology; 2007; 54(73):111-5. PubMed ID: 17419242.
    Abstract:
    BACKGROUND/AIMS: Postoperative pulmonary complications are often fatal in patients with esophageal cancer. The aim of this study was to clarify the association between cytokines and temporary ventilation during one-lung ventilation. METHODOLOGY: Serum and BALF IL-6, 8 were measured in 39 patients with esophageal cancer, and the relationship between cytokine response and temporary ventilation during one-lung ventilation in esophagectomy was examined. RESULTS: Pulmonary complications did not occur in our patients. Serum IL-6 levels were significantly increased in the high one-lung ventilation ratio and long-term one-lung ventilation groups. Serum IL-6 levels in the one or more times ventilation group during one-lung ventilation were significantly low compared to the no-ventilation group. There were no significant differences in serum IL-8 and BALF IL-6, 8 levels. CONCLUSIONS: Our results indicate that it is important to ventilate one or more times during one-lung ventilation in order to reduce postoperative pulmonary complications.
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