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  • Title: Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2.
    Author: Ho GD, Bercovici A, Tulshian D, Greenlee WJ, Fawzi A, Fernandez X, McLeod RL, Smith Torhan A, Zhang H.
    Journal: Bioorg Med Chem Lett; 2007 Jun 01; 17(11):3028-33. PubMed ID: 17420123.
    Abstract:
    A series of 4-[2-(aminomethyl)phenyl]-1-[bis(2-chlorophenyl)methyl]-4-hydroxypiperidine analogs has been identified as nociceptin receptor ligands. These compounds display high affinity and functional activity at the nociceptin receptor. The synthesis and structure-activity relationships at the C-4 phenyl and N-1 positions are described and the antitussive activity of a selected compound is reported.
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