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  • Title: Conserved amino acid residues in ribosome-inactivating proteins from plants.
    Author: Funatsu G, Islam MR, Minami Y, Sung-Sil K, Kimura M.
    Journal: Biochimie; 1991; 73(7-8):1157-61. PubMed ID: 1742358.
    Abstract:
    The amino acid sequences of eleven RIPs sequenced to date have been compared in the expectation that this would be useful in the location of functionally and/or structurally important sites of these molecules. In addition to several highly conserved hydrophobic amino acids, thirteen absolutely conserved residues have been found in ricin A-chain: Tyr21, Phe24, Arg29, Tyr80, Tyr123, Gly140, Ala165, Glu177, Ala178, Arg180, Glu208, Asn209 and Trp211. The role of these residues as well as of the C-terminal region have been discussed based on the results of chemical and enzymatic modifications, site-directed mutagenesis, and deletion studies.
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