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  • Title: Binding of FKBP23 to BiP in ER shown by gel filtration chromatography.
    Author: Chen C, Ma H, Wang Y, Mi H.
    Journal: Z Naturforsch C J Biosci; 2007; 62(1-2):133-7. PubMed ID: 17425118.
    Abstract:
    FKBP23 was found in mouse endoplasmic reticulum (ER) in 1998. It consists of an N-terminal peptidyl-prolyl cis/trans isomerase (PPIase) domain and a C-terminal domain with Ca2+ binding sites. Previously, we reported that FKBP23 specifically binds to BiP, the main protein of the molecular chaperone Hsp70 in ER lumen, and the binding is interrelated with the Ca2+ concentration. In this work we have found the existence of the complex FKBP23/BiP by separation of an ER extract using gel filtration chromatography (GFC), and that the existence of this complex is Ca2+-interrelated. This result further verified the Ca2+-interrelated binding of these two proteins in vivo.
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