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  • Title: [Radiosensitivity of nasopharyngeal carcinoma in relation to cell cycle synchronization effect of tumor necrosis factor alpha].
    Author: Yuan J, Sun N, Wang LJ, Tian W, Zhou XM, Chen DB, Gu HB.
    Journal: Nan Fang Yi Ke Da Xue Xue Bao; 2007 Mar; 27(3):374-6. PubMed ID: 17425997.
    Abstract:
    OBJECTIVE: To investigate the effect of tumor necrosis factor alpha (TNFalpha) on radiosensitivity of nasopharyngeal carcinoma (NPC) in relation to TNFalpha-induced cell cycle synchronization. METHODS: The radio-resistance of a NPC cell line subclone CNE-2Z-S1 was verified by in vivo experiments and flow cytometry was performed to evaluate cell cycle synchronization in TNFalpha-treated CNE-2Z-S1 cells. The radiosensitivity of the cell synchronized CNE-2Z-S1 cells was determined by clone formation in vitro and in vivo experiment in nude mice. RESULTS: TNFalpha was capable of inducing cell cycle arrest and synchronization of CNE-2Z-S1 cells. Pretreatment with TNFalpha remarkably enhanced the radiosensitivity of CNE-2Z-S1 in vitro, and in vivo experiments with nude mice also suggested the role of TNFalpha in enhancing the radiosensitivity of NPC. CONCLUSION: TNFalpha can enhance the radiosensitivity of NPC cells by inducing cell cycle synchronization.
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