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  • Title: Involvement of hippocampal metabotropic glutamate receptors in radial maze performance.
    Author: Hayashi K, Yoshihara T, Ichitani Y.
    Journal: Neuroreport; 2007 May 07; 18(7):719-23. PubMed ID: 17426606.
    Abstract:
    We investigated the role of hippocampal metabotropic glutamate receptors in spatial learning and memory, using an eight-arm radial maze task. (S)-4-Carboxyphenylglycine, a group I metabotropic glutamate receptor antagonist, or trans-(+/-)-1-amino-(1S,3R)-cyclopentanedicarboxylic acid, a broad-spectrum metabotropic glutamate receptor agonist, was administered into the dorsal hippocampus after rats had acquired the task. Both of these agents significantly impaired radial maze performance, suggesting a functional importance of hippocampal metabotropic glutamate receptors in spatial working memory.
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