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  • Title: Association analysis of COMT polymorphisms and schizophrenia in a Chinese Han population: a case-control study.
    Author: Yu R, Zhang XN, Huang XX, Ding SP, Li JC.
    Journal: Am J Med Genet B Neuropsychiatr Genet; 2007 Jun 05; 144B(4):570-3. PubMed ID: 17427186.
    Abstract:
    Schizophrenia is a common disease with complex mode of inheritance; great efforts have been made to identify the susceptible genes. Catechol-O-methyltransferase (COMT) gene has long been considered as a candidate gene mainly because of two reasons: First, it encodes a key dopamine catabolic enzyme. Second, it maps to the velocardiofacial syndrome (VCFS) region of chromosome 22q11, which is associated with schizophrenia predisposition. Numerous case-control and family-based studies have been conducted, majority of them focused on a functional Val/Met polymorphism (rs4680). Unfortunately, these studies have produced conflicting results. In a previous report, Shifman et al. found a three-marker haplotype (rs737865-rs4680-rs165599) that showed significant association with schizophrenia. In this study, we try to replicate their findings in Chinese Han population and failed to find any associations.
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