These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Fulminant Crohn's colitis: when only an antibody will do.
    Author: Ng SC, Kamm MA.
    Journal: Inflamm Bowel Dis; 2007 Aug; 13(8):971-4. PubMed ID: 17427240.
    Abstract:
    BACKGROUND: Fulminant Crohn's colitis complicated by toxic dilatation of the large bowel usually requires surgery, which carries a substantial morbidity and mortality rate. METHODS: We report the case of a female with steroid refractory fulminant Crohn's colitis complicated by toxic megacolon who was successfully treated with the antitumor necrosis factor monoclonal antibody adalimumab. RESULTS: Adalimumab induced rapid clinical response and remission, thereby avoiding emergency colectomy. CONCLUSIONS: This is the first report of treatment of fulminant Crohn's colitis with an antitumor necrosis factor antibody and the first report of the use of adalimumab for fulminant colitis of any cause.
    [Abstract] [Full Text] [Related] [New Search]