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  • Title: Determination and pharmacokinetics of manidipine in human plasma by HPLC/ESIMS.
    Author: Jing J, Ren W, Chen X, He H, Zhou W, Zhu X, Sun Y, Wang G.
    Journal: Biomed Chromatogr; 2007 Aug; 21(8):836-40. PubMed ID: 17428020.
    Abstract:
    A sensitive HPLC/ESIMS method was established for the determination of manidipine in human plasma and pharmacokinetics study. After basified plasma with ammonia, manidipine and the internal standard (IS) (felodipine) were extracted with n-hexane and separated on a Hypersil ODS2 column with a mobile phase of methanol-5 mm ammonium acetate solution containing 0.1% acetic acid (85:15, v/v). MS determination was performed by electrospray ionization in the selected ion monitoring mode. Manidipine was monitored at m/z 611.4 and IS at m/z 384. The assay had a calibration range from 0.2 to 20 ng/mL and a lower limit of quantification of 0.1 ng/mL. The method has been successfully applied to the pharmacokinetic study in healthy volunteers.
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