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  • Title: A tetra(L-lysine)-grafted poly(organophosphazene) for gene delivery.
    Author: Jun YJ, Kim JH, Choi SJ, Lee HJ, Jun MJ, Sohn YS.
    Journal: Bioorg Med Chem Lett; 2007 Jun 01; 17(11):2975-8. PubMed ID: 17428658.
    Abstract:
    In order to develop a new gene delivery vector, a novel cationic poly(organophosphazene) was synthesized by stepwise nucleophilic substitutions of poly(dichlorophosphazene) with a hydrophilic methoxy-poly(ethylene glycol) (MPEG) as a shielding group and a branched tetra(L-lysine), LysLys(LysEt)(2), as a cationic moiety. The cationic polymer has shown to form a polyplex by DNA condensation and very low in vitro cytotoxicity probably due to the shielding effect of MPEG, which provides a basis for improving the low gene transfection yield of cationic polyphosphazenes.
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