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  • Title: The effect of glycerol on the guinea-pig hydropic ear.
    Author: Magliulo G, Ungari C, Della Rocca C, Muscatello M, Vingolo GM.
    Journal: Clin Otolaryngol Allied Sci; 1991 Oct; 16(5):483-7. PubMed ID: 1742898.
    Abstract:
    The aim of this paper was to investigate the effect of glycerol on experimental endolymphatic hydrops in guinea-pigs. The right endolymphatic sac and duct were obliterated through an extradural posterior fossa approach. Some animals received a 3 g/kg dose of glycerol for a period of 7 days, whereas others received the same dose for 30 days. The activity of glycerol was studied by investigating the volumetric changes in the scala media determined with a computerized planimeter. Glycerol induced a significant reduction of the hydrops showing its effectiveness and suggesting a strial metabolic response.
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